Scientists manufacture many biotherapeutic products in immortalized cell lines, most commonly HEK293. Residual HEK293 DNA in biotherapeutic candidates can harbor tumorigenic or retroviral sequences ...

Potential guidance for decisions about treatment escalation, de-escalation ...

The epigenetic modification, DNA methylation, is characterized by 5-methylcytosine (5-mC) and found in specific genomic locations, most notably regulatory regions such as promoters and enhancers.

PCR genetic analysis has been in the spotlight since COVID-19, but light is now further facilitating PCR-free methods. Osaka Metropolitan University scientists have developed a light-induced DNA ...

In 2003, Kary Mullis took The Scientist readers behind the scenes of the night in 1983 when he came up with the idea for PCR. He included a photo of his lab notebook that depicts his very first ...

RT-PCR testing is showing up more often on dairies because it can find mastitis pathogens faster and more accurately than ...

Roughly one out of three women ages 14-49 in the United States develop a vaginal bacterial imbalance known as bacterial vaginosis (BV) during their lifetime. BV is characterized by unpleasant odors, ...

Human papillomavirus (HPV) is a double-stranded circular DNA virus with a genome of approximately 7–8 kb. This study aimed to ...

Researchers at Boston University have discovered an unexpectedly high prevalence of Mycobacterium tuberculosis DNA (TB DNA) ...