The Ever shorter telomeres 3 (Est3) protein is a small regulatory subunit of yeast telomerase which is dispensable for enzyme catalysis but essential for telomere replication in vivo. Using structure ...
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Why do we age? An answer in yeast
Why do our cells age? Part of the answer is hidden at the very ends of our chromosomes, where telomeres are located. These ...
Telomerase is essential for continuous cellular proliferation. Substantial insights have come from studies of budding yeast telomerase, which consists of a catalytic core in association with two ...
LA JOLLA, CA — It may take just one or two proteins to polish off a simple cellular task, but life-or-death matters, such as caring for the ends of chromosomes known as telomeres, require interacting ...
A key role in studying the telomerase of Hansenula polymorpha was played by KFU's nuclear magnetic resonance spectrometer. "The work frequency of our NMR spectrometer with a cryo sensor is 700 MHz. It ...
They found that, like several other telomeric proteins, Est3 exhibited an architectural element known as an "OB" fold. Using computer models to scrutinize the fold surface, the group predicted that ...
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