The mammalian diaphanous-related formins (mDIAs), originally characterized for their ability to nucleate unbranched actin, can also regulate microtubule stabilization during cell polarization and ...

Researchers have visualized at the molecular level how formins bind to the ends of actin filaments. This allowed them to uncover how formins mediate the addition of new actin molecules to a growing ...

There is increasing evidence that post-traumatic stress disorder (PTSD) increases the risk of developing dementia later in life. Researchers now shed light on the molecular mechanism that links the ...

Formins are made of two identical parts (red, orange) that encircle the actin (grey) filament in a ring-like conformation. “Our discovery allows us to interpret decades of biochemical studies on ...