A new review links three forces shaping osteoarthritis: mechanical stress, integrin signaling, and integrin endocytosis. The authors argue that integrin trafficking can reprogram where and how long ...
Concept figure summarizing the proposed regulatory axis connecting extracellular matrix mechanics to integrin signaling and receptor trafficking in joint cells.
Talin is a protein that plays an important role in the immune system by activating integrins, receptors that help cells attach to one another. Now a new study by Fox Chase Cancer Center researchers ...
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