The Human Domainome 1—the largest library of human protein variants—reveals the cause of certain genetic disorders, paving the way for personalized medicines. “We measured every possible mutation in ...

A comprehensive encyclopedia of the known functions of all protein-coding human genes has just been completed and released. Researchers used large-scale evolutionary modeling to integrate data on ...

To understand the human genome, scientists focused on protein-coding genes and their functions for decades. This has given us ...

Nucleic acid-based therapeutics, including antisense oligonucleotides (ASO), small interfering RNA (siRNA), messenger RNA (mRNA), immunomodulatory DNA/RNA, and gene-editing guide RNA (gRNA), hold ...

Scientists at the Children's Medical Center Research Institute at UT Southwestern (CRI) report that inactivating a certain protein-coding gene promotes liver tissue regeneration in mammals. "This ...

From viruses to humans, life makes microproteins that have evaded discovery until now. By Carl Zimmer You could be forgiven for assuming that scientists know how many kinds of proteins exist. After ...