A new single-cell atlas shows how epigenetic changes reshape brain cells during aging, revealing genomic instability, regional differences, and potential biomarkers of brain aging. More than 57 ...

A single-cell atlas of brain aging epigenetics has mapped methylation, chromatin, and gene activity changes across 36 cell types and 8 brain regions in mice, bringing new insights to aging and ...

Salk researchers create epigenetic atlas of cell type-specific changes in the aging mouse brain, representing eight different brain regions and 36 different cell types to show clear epigenetic ...

Biological tissues are made up of different cell types arranged in specific patterns, which are essential to their proper functioning. Understanding these spatial arrangements is important when ...

Certain cells in the brain create a nurturing environment, enhancing the health and resilience of their neighbors, while others promote stress and damage. Using spatial transcriptomics and AI, ...

In the brain, location is everything. And the throngs of cells that live there are nothing without the billions of distinct connections between them. Although scientists can use single-cell ...

This figure shows how the STAIG framework can successfully identify spatial domains by integrating image processing and contrastive learning to analyze spatial transcriptomics data effectively.