Recombinant serotype 5 adenovirus (Ad5) vectors lacking E1 expression induce robust immune responses against encoded transgenes in pre-clinical models, but have muted responses in human trials because ...
We recently reported on the use of the Ad5[E1-, E2b-] platform expressing the TAA carcnioembryoninc antigen (CEA) (Ad5[E1-, E2b-]-CEA) as an immunization and immunotherapeutic modality to induce TAA ...
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