Mount Sinai researchers have published the first organ-wide human skin spatial atlas from across the body. It provides an unprecedentedly detailed view of healthy human skin, revealing cellular ...

Knowing the location of a gene within intact tissue or a single cell allows scientists to unlock unknown cellular functions. This information is often lost in most genetic sequencing techniques, but ...

Single-cell RNA transcriptomics allows researchers to broadly profile the gene expression of individual cells in a particular tissue. This technique has allowed researchers to identify new subsets of ...

In this GEN Learning Lab, our expert panelists Linda Orzolek, MS, MB, Xuhuai Ji, MD, PhD, and Christina Chang, PhD, will discuss the current landscape of imaging- and next-generation sequencing-based ...

Breast cancer remains one of the most prevalent and life-threatening forms of cancer, impacting millions worldwide. This malignancy's heterogeneity and complexity have long posed significant ...

A single-cell atlas of brain aging epigenetics has mapped methylation, chromatin, and gene activity changes across 36 cell ...

Spatial transcriptomics (ST) technologies reveal the spatial organization of gene expression in tissues, providing critical insights into development, neurobiology, and cancer. However, the high cost ...

Initially, cells are dissociated from liver tissues into single-cell suspensions using in vivo enzymatic perfusion or ex vivo digestion methods. The cells of interest are then enriched from the ...

Neurodegenerative diseases affect more than 57 million people globally. The incidence of these diseases, from Alzheimer's to Parkinson's to ALS and beyond, is expected to double every 20 years. Though ...

This Research Topic is the second volume of the “Unraveling Breast Cancer Complexity: Insights from Single-Cell Sequencing and Spatial Transcriptomics” ...